Where to go from here...

My Dad was diagnosed with advanced prostate cancer in May.  He started with Lupron and that worked well for the first cycle.  His PSA went from 535 to 49.   Just before his second round of Lupron, his PSA increased to 59.   A week or two after the second round of Lupron, it increased again, this time to 69.   At this point, he was given Casodex.  I don't know for sure, but I believe he had a reaction to the Casodex.  The night of his first dosage, he experienced tremendous pain in his legs and pelvic area.   This continued for several days.  Finally, after consulting with the doctor, they advised him to stop taking the Casodex.   I have two questions for the board.  1.  If this was a reaction to Casodex and not something else, is there an alternative to Casodex/2. If the cancer is no longer responding to hormone treatment, what is the next alternative?   What specific drugs or treatements are appropriate.  ....and to add a third question, what else can we do?  My family and I are out of our wits with fear.   He did so well over the summer and now, I am very afraid that the cancer is becomming more agressive.  any help or comments would be greatly appreciated.