Studies from University Of Pennsylvania Further Understanding Of Prostate Cancer

It is established that androgen-dependent prostate cancer cells undergo apoptosis upon treatment with phorbol esters and related analogs, an effect primarily mediated by PKC delta. Treatment of LNCaP prostate cancer cells with phorbol 12-myristate 13-acetate (PMA) causes a strong and sustained activation of RhoA and its downstream effector ROCK(Rho kinase) as well as the formation of stress fibers, scientists in the United States report (see also Prostate Cancer).